1. Webcomics are one of the only places where you can do whatever you want with no one to answer to. Take advantage of it. Do the stories that you’ve always wanted to read but have never been able to find. Don’t make choices just based on what you think will be popular.
2. That said, learning to take criticism is a must! A lot of webcomics criticism is…not exactly constructive, but occasionally there will be a nugget of wisdom. Learn what to take to heart and what’s just noise.
3. Don’t be afraid to learn, experiment, and grow! If it’s your first longform comic, it’s some of the best comics education you can get.
4. This one isn’t applicable to every comic, but it’s important to me: be on time. Especially if you’re just starting out. Figure out your update schedule and stick to it. Have several pages drawn in advance so you’re not working up to the last minute. Updating on time shows your readership that you’re dedicated to the story and that you can consistently be relied upon to provide it. Obviously hiatuses have to happen sometimes, but if you’re new you can lose a lot of readers by not updating consistently when you’re getting started.
5. Keep on truckin’. Do it for the story and not for the fame and mad riches (because uh…there really isn’t any of that). It takes time and patience to build an audience, but having even just a few people care about the story you’re telling is an amazingly rewarding experience.